Growth hormone deficiency: When there is deficiency of growth hormone, the child fails to grow and is short, but could be otherwise normal, if other hormones are not deficient. Replacement of growth hormone, although very expensive, restores normal growth.

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Combined pituitary hormone deficiency: Sometimes a combination of anterior pituitary hormones are deficient, in which case, the features depend on the combination of deficient hormones . Replacement with hormones secreted by the end organs is effective.